Introduction: Periodic attacks of migraine can cause  some dysfunctionality such as long-term absence from work,  mood change, sleep disturbances  and ultimately change in quality of life. The aim of this study was to determine the effect of   educational program based on "Orem Self Care Model" on quality of life in patients with migraine. 

Materials and Methods:  In this quasi-experimental study, 42 patients with migraine were selected by convenience sampling referred to one of the traditional medical clinic of Tehran.  The data were collected with demographic data questionnaire and "Quality of Life Questionnaire for Patients with Migraine". The questionnaire was validated by content validity of ten experts and two neurologist physician.  Reliability of the questionnaire was confirmed by test-retest method. Orem's Self-Care Educational Program, was performed according to the patient needs during 2 hours in four sessions. The quality of life was measured in two stages before and 8 week after the study.  Data were analyzed with SPSS/14.

Findings: Average score of functions for the "physical" and "mental" status of the health, was increased before and after the study and it was significant (P=0.001).   In addition, there was a significant difference,   between mean scores of overall quality of life ,  before and after the study  (P=0.049).

Conclusions: Self-care educational program, based on "Ore m Self Care Model" and patients’ self-care needs, improves quality of life in the patients with migraine. It is recommended that this model be used to improve the quality of life in these patients.